View source for 8zxk


==Cryo-EM structure of trimethylamine transporter TmaT binding with TMA==
<StructureSection load='8zxk' size='340' side='right'caption='[[8zxk]], [[Resolution|resolution]] 2.76&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8zxk]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Myroides_profundi Myroides profundi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ZXK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ZXK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.76&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KEN:N,N-DIMETHYLMETHANAMINE'>KEN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8zxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8zxk OCA], [https://pdbe.org/8zxk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8zxk RCSB], [https://www.ebi.ac.uk/pdbsum/8zxk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8zxk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TMAT_MYRPR TMAT_MYRPR] Catalyzes the transport of trimethylamine (TMA) from the environment into the cell (PubMed:33771875). Binds TMA with high affinity, but does not bind trimethylamine N-oxide (TMAO), glycine betaine, carnitine, choline or dimethylsulfoniopropionate (DMSP) (PubMed:33771875). Together with the TMA monooxygenase Mptmm, is part of a two-step metabolic pathway that improves both growth and survival at high hydrostatic pressure (HHP) (PubMed:33771875).<ref>PMID:33771875</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Myroides profundi]]
[[Category: Chao G]]