View source for 8zxu


==Crystal structure of N terminal deletion mutant of Staphylococcal atypical two-cysteine thiol peroxidase complexed with substrate analog==
<StructureSection load='8zxu' size='340' side='right'caption='[[8zxu]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8zxu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ZXU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ZXU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1L2G:~{O}-~{tert}-butylhydroxylamine'>A1L2G</scene>, <scene name='pdbligand=DTO:1-HYDROXYSULFANYL-4-MERCAPTO-BUTANE-2,3-DIOL'>DTO</scene>, <scene name='pdbligand=DTU:(2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL'>DTU</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=PEO:HYDROGEN+PEROXIDE'>PEO</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8zxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8zxu OCA], [https://pdbe.org/8zxu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8zxu RCSB], [https://www.ebi.ac.uk/pdbsum/8zxu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8zxu ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TPX_STAAC TPX_STAAC] Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Staphylococcus aureus]]
[[Category: Bhattacharyya S]]
[[Category: Maji S]]
[[Category: Shukla M]]
[[Category: Yadav VK]]