View source for 9atn


==NMR structure of the MLL4 PHD2/3 fingers in complex with ASXL2==
<StructureSection load='9atn' size='340' side='right'caption='[[9atn]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9atn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9ATN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9ATN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9atn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9atn OCA], [https://pdbe.org/9atn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9atn RCSB], [https://www.ebi.ac.uk/pdbsum/9atn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9atn ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/KMT2D_HUMAN KMT2D_HUMAN] Kabuki syndrome. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/KMT2D_HUMAN KMT2D_HUMAN] Histone methyltransferase. Methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription.<ref>PMID:16603732</ref> <ref>PMID:17500065</ref> <ref>PMID:17851529</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Kutateladze T]]
[[Category: Zandian M]]
[[Category: Zhang Y]]