View source for 9ayr


==Structure of a Ric1-Rgp1-Rab6 activation intermediate==
<StructureSection load='9ayr' size='340' side='right'caption='[[9ayr]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9ayr]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9AYR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9AYR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ayr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ayr OCA], [https://pdbe.org/9ayr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ayr RCSB], [https://www.ebi.ac.uk/pdbsum/9ayr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ayr ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RIC1_YEAST RIC1_YEAST] The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates YPT6 by exchanging bound GDP for free GTP. It is thereby required for efficient fusion of endosome-derived vesicles with the Golgi. The RIC1-RGP1 participates in the recycling of SNC1, presumably by mediating fusion of endosomal vesicles with the Golgi compartment. May also be indirectly involved in the transcription of both ribosomal protein genes and ribosomal RNA.<ref>PMID:10990452</ref> <ref>PMID:11160819</ref> <ref>PMID:11689439</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Feathers JR]]
[[Category: Fromme JC]]