View source for 9b9t


==Crystal structure of the ternary complex of DCAF1 and WDR5 with PROTAC, OICR-40407==
<StructureSection load='9b9t' size='340' side='right'caption='[[9b9t]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9b9t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9B9T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9B9T FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1ANM:~{N}-[5-[5-[2-[2-[2-[2-[2-[2-[4-[4-[[(1~{S})-3-azanyl-1-(3-chloranyl-4-fluoranyl-phenyl)-3-oxidanylidene-propyl]carbamoyl]-3-(4-chloranyl-2-fluoranyl-phenyl)-1~{H}-pyrrol-2-yl]pyrazol-1-yl]ethanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethylcarbamoyl]-2-fluoranyl-phenyl]-2-[(3~{S},5~{R})-3,4,5-trimethylpiperazin-1-yl]phenyl]-6-oxidanylidene-4-(trifluoromethyl)-1~{H}-pyridine-3-carboxamide'>A1ANM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9b9t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9b9t OCA], [https://pdbe.org/9b9t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9b9t RCSB], [https://www.ebi.ac.uk/pdbsum/9b9t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9b9t ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Al-awar R]]
[[Category: Hoffer L]]
[[Category: Krausser C]]
[[Category: Mabanglo MF]]
[[Category: Vedadi M]]
[[Category: Wilson BJ]]