View source for 9bji


==Cryo-EM structure of apo NVL==
<StructureSection load='9bji' size='340' side='right'caption='[[9bji]], [[Resolution|resolution]] 2.83&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9bji]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_BL21(DE3) Escherichia coli BL21(DE3)] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9BJI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9BJI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.83&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9bji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9bji OCA], [https://pdbe.org/9bji PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9bji RCSB], [https://www.ebi.ac.uk/pdbsum/9bji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9bji ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NVL_HUMAN NVL_HUMAN] Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT (PubMed:22226966). Involved in both early and late stages of the pre-rRNA processing pathways (PubMed:26166824). Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus (PubMed:15469983, PubMed:16782053, PubMed:29107693, PubMed:26456651). Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity (PubMed:29107693, PubMed:26456651, PubMed:28416111).<ref>PMID:15469983</ref> <ref>PMID:16782053</ref> <ref>PMID:22226966</ref> <ref>PMID:26166824</ref> <ref>PMID:26456651</ref> <ref>PMID:28416111</ref> <ref>PMID:29107693</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cruz VE]]
[[Category: Erzberger JP]]