View source for 9bnc


==Collagen XVIII trimerization domain with introduced inter-chain disulfide bond, E31C-V37C==
<StructureSection load='9bnc' size='340' side='right'caption='[[9bnc]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9bnc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9BNC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9BNC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9bnc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9bnc OCA], [https://pdbe.org/9bnc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9bnc RCSB], [https://www.ebi.ac.uk/pdbsum/9bnc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9bnc ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/COIA1_HUMAN COIA1_HUMAN] Defects in COL18A1 are a cause of Knobloch syndrome type 1 (KNO1) [MIM:[https://omim.org/entry/267750 267750]. An autosomal recessive disorder defined by the occurrence of high myopia, vitreoretinal degeneration with retinal detachment, macular abnormalities and occipital encephalocele.<ref>PMID:10942434</ref> 
== Function ==
[https://www.uniprot.org/uniprot/COIA1_HUMAN COIA1_HUMAN] COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube.  Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Young T]]