View source for 9bqa


==Human Topoisomerase 2 Beta ATPase domain bound to BNS22 and non-hydrolyzable ATP analog AMPPNP==
<StructureSection load='9bqa' size='340' side='right'caption='[[9bqa]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9bqa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9BQA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9BQA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1ASD:8-(3,4-dihydroquinoline-1(2H)-carbonyl)-5,7-dimethoxy-4-propyl-2H-1-benzopyran-2-one'>A1ASD</scene>, <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9bqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9bqa OCA], [https://pdbe.org/9bqa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9bqa RCSB], [https://www.ebi.ac.uk/pdbsum/9bqa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9bqa ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TOP2B_HUMAN TOP2B_HUMAN] Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.<ref>PMID:10684600</ref> <ref>PMID:12837248</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Alvey JA]]
[[Category: Applova L]]
[[Category: Arrouye L]]
[[Category: Austin CA]]
[[Category: Cong ATQ]]
[[Category: Jirkovska A]]
[[Category: Karabanovich G]]
[[Category: Kerestes V]]
[[Category: Kollarova P]]
[[Category: Kubes J]]
[[Category: Kunes J]]
[[Category: Lencova O]]
[[Category: Melnikova I]]
[[Category: Paluncic J]]
[[Category: Piskackova HB]]
[[Category: Roh J]]
[[Category: Schellenberg MJ]]
[[Category: Simunek T]]
[[Category: Sterba M]]
[[Category: Sterbova P]]
[[Category: Witter TL]]