View source for 9bvu


==NMR structure of TLP-2 in solution==
<StructureSection load='9bvu' size='340' side='right'caption='[[9bvu]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9bvu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rana_temporaria Rana temporaria]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9BVU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9BVU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9bvu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9bvu OCA], [https://pdbe.org/9bvu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9bvu RCSB], [https://www.ebi.ac.uk/pdbsum/9bvu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9bvu ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TPL_RANTE TPL_RANTE] Amphipathic alpha-helical antimicrobial peptide with potent activity against both Gram-negative and Gram-positive bacteria, and against fungi (PubMed:12133008, PubMed:16867990, PubMed:18370376, PubMed:31358802, PubMed:9022710). Mainly acts by causing perturbation of bilayer integrity of both neutral and negatively charged membranes, probably by forming pore-like openings (PubMed:12133008, PubMed:31358802). Also displays anti-leishmania activity by damaging parasite membrane (By similarity). Shows hemolytic activity (PubMed:12133008). Also shows cytotoxicity against cancer cell lines (PubMed:12133008). Strongly binds to lipopolysaccharides (LPS) and its lipid A portion (Probable) (PubMed:16801429). Improves temporin-A and temporin-B activities by preventing their homo-oligomerization in LPS (PubMed:16867990, PubMed:21586570). In vivo, its simultaneous administration with beta-lactam antibiotics produces the highest antimicrobial activities and the strongest reduction in plasma LPS and TNF-alpha levels, resulting in the highest survival rates in rat models of septic shock (PubMed:16801429).[UniProtKB:P56917][UniProtKB:P79874]<ref>PMID:12133008</ref> <ref>PMID:16801429</ref> <ref>PMID:16867990</ref> <ref>PMID:18370376</ref> <ref>PMID:21586570</ref> <ref>PMID:31358802</ref> <ref>PMID:9022710</ref> <ref>PMID:21586570</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Rana temporaria]]
[[Category: Jia R]]
[[Category: McShan AC]]