View source for 9caf


==Cryo-EM structure of the reconstituted TRRAP lobe of the human TIP60 complex (composite structure)==
<StructureSection load='9caf' size='340' side='right'caption='[[9caf]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9caf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9CAF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9CAF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9caf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9caf OCA], [https://pdbe.org/9caf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9caf RCSB], [https://www.ebi.ac.uk/pdbsum/9caf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9caf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/EP400_HUMAN EP400_HUMAN] Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome.<ref>PMID:14966270</ref> <ref>PMID:24463511</ref> [https://www.uniprot.org/uniprot/DHAA_PSEPV DHAA_PSEPV] Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons. Has a broad substrate specificity, as it is able to dehalogenate mono- and di- chlorinated and brominated alkanes (up to at least C10), and the two isomers of 1,3-dichloropropene to 3-chloroallyl alcohol; the highest activity was found with 1,2-dibromoethane, while no activity was observed with the analog 1,2-dichloroethane.<ref>PMID:9687453</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Louder RK]]
[[Category: Park G]]
[[Category: Patel AB]]