View source for 9ccf


==Crystal Structure of DA7-2==
<StructureSection load='9ccf' size='340' side='right'caption='[[9ccf]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9ccf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9CCF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9CCF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ccf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ccf OCA], [https://pdbe.org/9ccf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ccf RCSB], [https://www.ebi.ac.uk/pdbsum/9ccf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ccf ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/PDYN_HUMAN PDYN_HUMAN] Spinocerebellar ataxia type 23. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/PDYN_HUMAN PDYN_HUMAN] Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity).  Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin (By similarity).  Leumorphin has a typical opiod activity and may have anti-apoptotic effect.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Baker D]]
[[Category: Bera AK]]
[[Category: Kang A]]
[[Category: Wu K]]