View source for 9cfc


==Cryo-EM structure of human kidney V-ATPase state 2==
<StructureSection load='9cfc' size='340' side='right'caption='[[9cfc]], [[Resolution|resolution]] 3.47&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9cfc]] is a 26 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9CFC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9CFC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.47&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9cfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9cfc OCA], [https://pdbe.org/9cfc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9cfc RCSB], [https://www.ebi.ac.uk/pdbsum/9cfc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9cfc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VATO_HUMAN VATO_HUMAN] Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).[UniProtKB:Q2TA24]<ref>PMID:33065002</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Lyu M]]
[[Category: Zhang Z]]