View source for 9cft


==Adeno-associated virus serotype 6 basic regions in complex with importin alpha 2==
<StructureSection load='9cft' size='340' side='right'caption='[[9cft]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9cft]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Adeno-associated_virus_-_6 Adeno-associated virus - 6] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9CFT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9CFT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9cft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9cft OCA], [https://pdbe.org/9cft PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9cft RCSB], [https://www.ebi.ac.uk/pdbsum/9cft PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9cft ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IMA1_MOUSE IMA1_MOUSE] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
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</StructureSection>
[[Category: Adeno-associated virus - 6]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Forwood JK]]
[[Category: Hoad M]]