View source for 9cjz


==CryoEM structure of NC99 hemagglutinin trimer in complex with Fab T009 3-E04==
<StructureSection load='9cjz' size='340' side='right'caption='[[9cjz]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9cjz]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus] and [https://en.wikipedia.org/wiki/Macaca_fascicularis Macaca fascicularis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9CJZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9CJZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9cjz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9cjz OCA], [https://pdbe.org/9cjz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9cjz RCSB], [https://www.ebi.ac.uk/pdbsum/9cjz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9cjz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q6WG00_9INFA Q6WG00_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[SAAS:SAAS00204388]
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</StructureSection>
[[Category: Influenza A virus]]
[[Category: Large Structures]]
[[Category: Macaca fascicularis]]
[[Category: Kanekiyo M]]
[[Category: Li N]]
[[Category: Sangesland M]]
[[Category: Tsybovsky Y]]