View source for 9clb


==Crystal structure of Bak bound to the inhibitory aBAK==
<StructureSection load='9clb' size='340' side='right'caption='[[9clb]], [[Resolution|resolution]] 2.86&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9clb]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9CLB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9CLB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.86&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9clb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9clb OCA], [https://pdbe.org/9clb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9clb RCSB], [https://www.ebi.ac.uk/pdbsum/9clb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9clb ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BAK_HUMAN BAK_HUMAN] In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis.<ref>PMID:8521816</ref> <ref>PMID:17157251</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Arguinchona L]]
[[Category: Baker D]]
[[Category: Bera AK]]
[[Category: Berger SA]]
[[Category: Birkinshaw RW]]
[[Category: Colman PM]]
[[Category: Czabotar PE]]
[[Category: Fairlie WD]]
[[Category: Harris TJ]]
[[Category: Kang A]]
[[Category: Kasapgil S]]
[[Category: Kluck R]]
[[Category: Lee EF]]
[[Category: Miller MS]]
[[Category: Sankaran B]]
[[Category: Smyth S]]
[[Category: Tran S]]
[[Category: Uren R]]