View source for 9coj


==SH3-like tandem domain of human KIN protein==
<StructureSection load='9coj' size='340' side='right'caption='[[9coj]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9coj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9COJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9COJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9coj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9coj OCA], [https://pdbe.org/9coj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9coj RCSB], [https://www.ebi.ac.uk/pdbsum/9coj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9coj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KIN17_HUMAN KIN17_HUMAN] Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity). Binds via its C-terminal domain to RNA in vitro.[UniProtKB:Q8K339]<ref>PMID:11880372</ref> <ref>PMID:12359749</ref> <ref>PMID:12754299</ref> <ref>PMID:12853634</ref> <ref>PMID:15831485</ref> <ref>PMID:17045609</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Almeida FCL]]
[[Category: Caruso IP]]
[[Category: Fernandez MA]]
[[Category: Fossey MA]]
[[Category: Seixas FAV]]
[[Category: Souza FP]]
[[Category: De Lourenco IO]]