View source for 9cum


==Q67H mutant of R67 DHFR complexed with Congo Red==
<StructureSection load='9cum' size='340' side='right'caption='[[9cum]], [[Resolution|resolution]] 1.15&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9cum]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9CUM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9CUM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.15&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CGO:SODIUM+3,3-(1E,1E)-BIPHENYL-4,4-DIYLBIS(DIAZENE-2,1-DIYL)BIS(4-AMINONAPHTHALENE-1-SULFONATE)'>CGO</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9cum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9cum OCA], [https://pdbe.org/9cum PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9cum RCSB], [https://www.ebi.ac.uk/pdbsum/9cum PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9cum ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DYR21_ECOLX DYR21_ECOLX] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Narayana N]]
[[Category: Narendra AN]]