View source for 9cyq


==Crystal structure of Q78R mutant human PTP1B (PTPN1) at room temperature (298 K)==
<StructureSection load='9cyq' size='340' side='right'caption='[[9cyq]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9cyq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9CYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9CYQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9cyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9cyq OCA], [https://pdbe.org/9cyq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9cyq RCSB], [https://www.ebi.ac.uk/pdbsum/9cyq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9cyq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bounds R]]
[[Category: Ebrahim A]]
[[Category: Farooqi IS]]
[[Category: Henning E]]
[[Category: Keedy DA]]
[[Category: Keogh JM]]
[[Category: Lawler K]]
[[Category: Mehlman T]]
[[Category: Morris JW]]
[[Category: Perdikari A]]
[[Category: Riley BT]]
[[Category: Sharma S]]
[[Category: Singh NI]]
[[Category: Smith M]]
[[Category: Woods VA]]