View source for 9dlu


==Solution structure of Staphylococcus aureus response regulator ArlR DNA-binding domain==
<StructureSection load='9dlu' size='340' side='right'caption='[[9dlu]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9dlu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_NCTC_8325 Staphylococcus aureus subsp. aureus NCTC 8325]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9DLU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9DLU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9dlu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9dlu OCA], [https://pdbe.org/9dlu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9dlu RCSB], [https://www.ebi.ac.uk/pdbsum/9dlu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9dlu ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ARLR_STAA8 ARLR_STAA8] Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence. ArlS/ArlR affects expression of the multidrug resistance transporter NorA and interacts with both Agr (virulence accessory gene regulator) (negatively) and SarA (staphylococcal accessory regulator) (positively) to modulate several virulence factor genes, including ssp (serine protease), spa (surface protein A) and hla (alpha-hemolysin). Could inhibit biofilm development by a mechanism independent of the presence of the poly-N-acetylglucosamine (PNAG). Also, Arl proteins are required for the efficient activity of DNA gyrase inhibitors and high osmolarity on spa expression.<ref>PMID:10633099</ref> <ref>PMID:10869073</ref> <ref>PMID:11454217</ref> <ref>PMID:15528666</ref> <ref>PMID:16030226</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Staphylococcus aureus subsp. aureus NCTC 8325]]
[[Category: Hwang P]]
[[Category: Rafid Feisal M]]