View source for 9dnc


==Apo crystal structure of RamR variant D2.1==
<StructureSection load='9dnc' size='340' side='right'caption='[[9dnc]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9dnc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9DNC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9DNC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9dnc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9dnc OCA], [https://pdbe.org/9dnc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9dnc RCSB], [https://www.ebi.ac.uk/pdbsum/9dnc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9dnc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HTHTR_SALTY HTHTR_SALTY] Transcriptional regulator (PubMed:18443112, PubMed:22948865, PubMed:23800819, PubMed:30655545). Represses the transcription of the transcriptional activator RamA and, thereby, leads to repression of the expression of the efflux pump subunits AcrA and AcrB, and TolC (PubMed:18443112, PubMed:22948865, PubMed:23800819, PubMed:30655545). Acts by binding directly to the promoter region of the ramA gene (PubMed:22123696, PubMed:22948865, PubMed:23800819). Promoter binding may be inhibited partially by the small regulatory RNA StyR3, perhaps thereby ensuring a basal level of expression of RamA.[UniProtKB:A0A0H3GJQ8]<ref>PMID:18443112</ref> <ref>PMID:22123696</ref> <ref>PMID:22948865</ref> <ref>PMID:23800819</ref> <ref>PMID:30655545</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
[[Category: Kim W]]
[[Category: Zhang YJ]]