View source for 9doa


==Membrane-bound OlyA/PlyB (Hinge-Lock) prepore==
<StructureSection load='9doa' size='340' side='right'caption='[[9doa]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9doa]] is a 39 chain structure with sequence from [https://en.wikipedia.org/wiki/Pleurotus_ostreatus Pleurotus ostreatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9DOA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9DOA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.99&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9doa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9doa OCA], [https://pdbe.org/9doa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9doa RCSB], [https://www.ebi.ac.uk/pdbsum/9doa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9doa ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/OLYA6_PLEOS OLYA6_PLEOS] Has hemolytic activity against bovine erythrocytes at nanomolar concentrations in vitro. Promotes active pleurotolysin B (PlyB)-dependent permeabilization of membranes rich in cholesterol and sphingomyelin. May play an important role in the initial phase of fungal fruiting.<ref>PMID:12020804</ref> <ref>PMID:23806422</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pleurotus ostreatus]]
[[Category: Chen Z]]
[[Category: Han Y]]
[[Category: Li Y]]
[[Category: Radhakrishnan A]]
[[Category: Smothers J]]