View source for 9dzm


==Dimeric human OCT2 (POU2F2) POU domain bound to palindromic MORE DNA==
<StructureSection load='9dzm' size='340' side='right'caption='[[9dzm]], [[Resolution|resolution]] 2.54&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9dzm]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9DZM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9DZM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.54&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9dzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9dzm OCA], [https://pdbe.org/9dzm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9dzm RCSB], [https://www.ebi.ac.uk/pdbsum/9dzm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9dzm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PO2F2_HUMAN PO2F2_HUMAN] Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter.<ref>PMID:2904654</ref> <ref>PMID:2328728</ref> <ref>PMID:2901913</ref> <ref>PMID:1739980</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Poon GMK]]
[[Category: Terrell JR]]