View source for 9ea3


==T4 bacteriophage replicative holoenzyme containing triple mutations D75R, Q430E, and K432E in the exonuclease-deficient polymerase==
<StructureSection load='9ea3' size='340' side='right'caption='[[9ea3]], [[Resolution|resolution]] 3.99&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9ea3]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_phage_T4 Escherichia phage T4] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9EA3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9EA3 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.99&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ea3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ea3 OCA], [https://pdbe.org/9ea3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ea3 RCSB], [https://www.ebi.ac.uk/pdbsum/9ea3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ea3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A7S9SVB6_BPT4 A0A7S9SVB6_BPT4] Replicates the viral genomic DNA. This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction for proofreading purpose.[HAMAP-Rule:MF_04100]
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</StructureSection>
[[Category: Escherichia phage T4]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Feng X]]
[[Category: Li H]]