View source for 9ebr


==The structure of NiaR from Thermotoga maritima bound to nicotinic acid==
<StructureSection load='9ebr' size='340' side='right'caption='[[9ebr]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9ebr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9EBR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9EBR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=NIO:NICOTINIC+ACID'>NIO</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ebr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ebr OCA], [https://pdbe.org/9ebr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ebr RCSB], [https://www.ebi.ac.uk/pdbsum/9ebr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ebr ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NIAR_THEMA NIAR_THEMA] Probably functions to regulate transcription of NAD metabolic genes. Binds to DNA upstream of the probable nadBII/nadA/nadC and niaRP operons in a nicotinic acid dependent fashion. Nicotinic acid may be a corepressor.
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</StructureSection>
[[Category: Large Structures]]
[[Category: Thermotoga maritima]]
[[Category: Cheng DWC]]
[[Category: Glasfeld A]]
[[Category: Li Y]]