View source for 9efh


==The prefusion conformation of herpes simplex virus type 1 (HSV-1) glycoprotein B (gB) mutant R131F==
<StructureSection load='9efh' size='340' side='right'caption='[[9efh]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9efh]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_F Human alphaherpesvirus 1 strain F]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9EFH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9EFH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9efh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9efh OCA], [https://pdbe.org/9efh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9efh RCSB], [https://www.ebi.ac.uk/pdbsum/9efh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9efh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GB_HHV1F GB_HHV1F] Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moities of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding of gD to one of its receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress. Also plays a role, together with gK, in virus-induced cell-to-cell fusion (syncytia formation) (By similarity).<ref>PMID:17548810</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Human alphaherpesvirus 1 strain F]]
[[Category: Large Structures]]
[[Category: Dai X]]
[[Category: Mou Z]]
[[Category: Wang S]]