View source for 9efw


==Co-crystal structure of yeast Forkhead transcription factor Fkh1 bound to DNA==
<StructureSection load='9efw' size='340' side='right'caption='[[9efw]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9efw]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9EFW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9EFW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9efw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9efw OCA], [https://pdbe.org/9efw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9efw RCSB], [https://www.ebi.ac.uk/pdbsum/9efw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9efw ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FKH1_YEAST FKH1_YEAST] Transcription factor that regulates the expression of the CLB2 cluster of genes during the G2/M phase of the mitotic cell cycle (PubMed:10894548, PubMed:10894549, PubMed:10959837, PubMed:11562353, PubMed:12702877, PubMed:17283050, PubMed:24504085). The CLB2 cluster of genes includes mitotic regulators such as CLB1, CLB2, CDC5 and CDC20 as well as SWI5 and ACE2, transcription factors required for the subsequent temporal wave of cell cycle regulated gene expression in the M/G1 phase interval (PubMed:10894548, PubMed:10959837, PubMed:11562353). Involved in HMRa silencing (PubMed:10747051). FKH1 and FKH2 associate with the coding regions of active genes and influence, in opposing ways, transcriptional elongation and termination, and coordinate early transcription elongation and pre-mRNA processing (PubMed:12702877). Both FKH1 and FKH2 play a role as regulators of lifespan in collaboration with the anaphase-promoting complex (APC), likely through combined regulation of stress response, genomic stability, and cell cycle regulation (PubMed:22438832). FKH1 and FKH2 function also in controlling yeast cell morphology by preventing preudohyphal growth (PubMed:10747051, PubMed:10894548). Acts as a rate-limiting replication origin activator via its interaction with the origin recognition complex (ORC) (PubMed:22265405, PubMed:26728715). Plays a transcription-independent role in recombination donor preference during mating-type switching through binding to the recombination enhancer (RE), a 700-bp cis-acting element that controls recombination along the left arm of chromosome III (PubMed:12183363, PubMed:16809780, PubMed:22496671, PubMed:27257873).<ref>PMID:10747051</ref> <ref>PMID:10894548</ref> <ref>PMID:10894549</ref> <ref>PMID:10959837</ref> <ref>PMID:11562353</ref> <ref>PMID:12183363</ref> <ref>PMID:12702877</ref> <ref>PMID:16809780</ref> <ref>PMID:17283050</ref> <ref>PMID:22265405</ref> <ref>PMID:22438832</ref> <ref>PMID:22496671</ref> <ref>PMID:24504085</ref> <ref>PMID:26728715</ref> <ref>PMID:27257873</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Synthetic construct]]
[[Category: Aparicio OM]]
[[Category: Batyuk A]]
[[Category: Cherezov V]]
[[Category: Jiang Y]]
[[Category: Nasertorabi F]]
[[Category: Rohs R]]
[[Category: Sun Y]]
[[Category: Wang GL]]