View source for 9egj


==Crystal Structure of EgtUC binding domain mutant I243P bound to L-Ergothioneine from S. pneumoniae==
<StructureSection load='9egj' size='340' side='right'caption='[[9egj]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9egj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_D39 Streptococcus pneumoniae D39]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9EGJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9EGJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.89&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LW8:trimethyl-[(2~{S})-1-oxidanyl-1-oxidanylidene-3-(2-sulfanylidene-1,3-dihydroimidazol-4-yl)propan-2-yl]azanium'>LW8</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9egj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9egj OCA], [https://pdbe.org/9egj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9egj RCSB], [https://www.ebi.ac.uk/pdbsum/9egj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9egj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/EGTUB_STRP2 EGTUB_STRP2] Part of an ABC transporter complex EgtU required for the uptake of ergothioneine (EGT), a natural low-molecular weight (LMW) thiol antioxidant (PubMed:36481738). Responsible for the translocation of the substrate across the membrane (PubMed:36481738). Also contains a C-terminal periplasmic solute-binding domain (SBD) which binds to EGT with sub-micromolar affinity (PubMed:36481738). Binds L-hercynine about 10,000-fold less tightly than EGT (PubMed:36481738). Cannot bind the structurally similar compounds L-histidine, proline-betaine, choline, ectoine, carnitine or dimethylpropiothetin (PubMed:36481738).<ref>PMID:36481738</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Streptococcus pneumoniae D39]]
[[Category: Giedroc DP]]
[[Category: Gonzalez-Gutierrez G]]
[[Category: Legg KA]]