View source for 9ehu


==Crystal structure of the Gamak virus attachment protein head domain==
<StructureSection load='9ehu' size='340' side='right'caption='[[9ehu]], [[Resolution|resolution]] 1.42&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9ehu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Measles_morbillivirus Measles morbillivirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9EHU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9EHU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.42&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ehu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ehu OCA], [https://pdbe.org/9ehu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ehu RCSB], [https://www.ebi.ac.uk/pdbsum/9ehu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ehu ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
Henipaviruses, a genus within the Paramyxoviridae family, include the highly virulent Nipah and Hendra viruses that cause reoccurring outbreaks of deadly disease (1) . Recent discoveries of several new Paramyxoviridae species, including the zoonotic Langya virus (2) , have revealed much higher antigenic diversity than currently characterized and prompted the reorganization of these viruses into the Henipavirus and Parahenipavirus genera (3) . Here, to explore the limits of structural and antigenic variation in both genera, collectively referred to here as HNVs, we constructed an expanded, antigenically diverse panel of HNV fusion and attachment glycoproteins from 56 unique HNV strains that better reflects global HNV diversity. We expressed and purified the fusion protein ectodomains and the attachment protein head domains and characterized their biochemical, biophysical and structural properties. We performed immunization experiments in mice leading to the elicitation of antibodies reactive to multiple HNV fusion proteins. Cryo-electron microscopy structures of diverse fusion proteins elucidated molecular determinants of differential pre-fusion state metastability and higher order contacts. A crystal structure of the Gamak virus attachment head domain revealed an additional domain added to the conserved 6-bladed, beta-propeller fold. Taken together, these studies expand the known structural and antigenic limits of the HNVs, reveal new cross-reactive epitopes within both genera and provide foundational data for the development of broadly reactive countermeasures.

Structural and Antigenic Characterization of Novel and Diverse Henipavirus Glycoproteins.,May AJ, Lella M, Lindenberger J, Berkman A, Kumar U, Dutta M, Barr M, Parks R, Newman A, Huang X, Song K, Ilevbare V, Sammour S, Park CS, Adhikari RD, Devkota P, Janowska K, Liu Y, Scapellato G, Spence TN, Mansouri K, Edwards RJ, Saunders KO, Haynes BF, Acharya P bioRxiv [Preprint]. 2025 Feb 25:2024.12.11.627382. doi: , 10.1101/2024.12.11.627382. PMID:39713338<ref>PMID:39713338</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Measles morbillivirus]]
[[Category: Acharya P]]
[[Category: Lindenberger J]]