View source for 9ejz


==Human M5 muscarinic acetylcholine receptor complex with mini-Gq, agonist acetylcholine and positive allosteric modulator VU6007678==
<StructureSection load='9ejz' size='340' side='right'caption='[[9ejz]], [[Resolution|resolution]] 2.06&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9ejz]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Lama_glama Lama glama], [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9EJZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9EJZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.06&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1BKS:~{N}-[(1~{R})-4-fluoranyl-2,3-dihydro-1~{H}-inden-1-yl]-1-(1~{H}-indazol-5-ylsulfonyl)-~{N}-propyl-piperidine-4-carboxamide'>A1BKS</scene>, <scene name='pdbligand=ACH:ACETYLCHOLINE'>ACH</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ejz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ejz OCA], [https://pdbe.org/9ejz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ejz RCSB], [https://www.ebi.ac.uk/pdbsum/9ejz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ejz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GBB1_RAT GBB1_RAT] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Lama glama]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Rattus norvegicus]]
[[Category: Burger WAC]]
[[Category: Mobbs JI]]
[[Category: Thal DM]]