View source for 9ekd


==Structure of a C1r Zymogen Fragment Bound to SALO==
<StructureSection load='9ekd' size='340' side='right'caption='[[9ekd]], [[Resolution|resolution]] 3.28&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9ekd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lutzomyia_longipalpis Lutzomyia longipalpis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9EKD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9EKD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.28&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TYS:O-SULFO-L-TYROSINE'>TYS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ekd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ekd OCA], [https://pdbe.org/9ekd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ekd RCSB], [https://www.ebi.ac.uk/pdbsum/9ekd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ekd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SALO_LUTLO SALO_LUTLO] Salivary protein that inhibits the classical pathway of complement system activation in the host while having no inhibitory effect on the alternative or lectin pathways (PubMed:26758086, PubMed:28278244). Prevent cleavage of host C4 and consequently impairs the activation of factors downstream of C4b in the complement cascade (PubMed:26758086).<ref>PMID:26758086</ref> <ref>PMID:28278244</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Lutzomyia longipalpis]]
[[Category: Duan H]]
[[Category: Geisbrecht BV]]