View source for 9en4


==VP8* domain of the spike protein VP4 from bovine P[3] strain of rotavirus species C==
<StructureSection load='9en4' size='340' side='right'caption='[[9en4]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9en4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovine_rotavirus_C Bovine rotavirus C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9EN4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9EN4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9en4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9en4 OCA], [https://pdbe.org/9en4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9en4 RCSB], [https://www.ebi.ac.uk/pdbsum/9en4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9en4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/L0N4C6_9REOV L0N4C6_9REOV] Outer capsid protein VP4: Spike-forming protein that mediates virion attachment to the host epithelial cell receptors and plays a major role in cell penetration, determination of host range restriction and virulence. Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors. It is subsequently lost, together with VP7, following virus entry into the host cell. Following entry into the host cell, low intracellular or intravesicular Ca(2+) concentration probably causes the calcium-stabilized VP7 trimers to dissociate from the virion. This step is probably necessary for the membrane-disrupting entry step and the release of VP4, which is locked onto the virion by VP7.[HAMAP-Rule:MF_04125]  Outer capsid protein VP8*: Forms the head of the spikes and mediates the recognition of specific host cell surface glycans. It is the viral hemagglutinin and an important target of neutralizing antibodies.[HAMAP-Rule:MF_04125]
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</StructureSection>
[[Category: Bovine rotavirus C]]
[[Category: Large Structures]]
[[Category: Casino F]]
[[Category: Paredes-Martinez F]]