View source for 9eo4


==Outward-open structure of human dopamine transporter bound to cocaine==
<StructureSection load='9eo4' size='340' side='right'caption='[[9eo4]], [[Resolution|resolution]] 2.66&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9eo4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9EO4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9EO4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.66&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=COC:COCAINE'>COC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9eo4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9eo4 OCA], [https://pdbe.org/9eo4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9eo4 RCSB], [https://www.ebi.ac.uk/pdbsum/9eo4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9eo4 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/SC6A3_HUMAN SC6A3_HUMAN] Infantile dystonia-parkinsonism. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/SC6A3_HUMAN SC6A3_HUMAN] Mediates sodium- and chloride-dependent transport of dopamine (PubMed:10375632, PubMed:11093780, PubMed:1406597, PubMed:15505207, PubMed:19478460, PubMed:8302271). Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline) (By similarity). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (By similarity).[UniProtKB:P23977][UniProtKB:Q61327]<ref>PMID:1406597</ref> <ref>PMID:15505207</ref> <ref>PMID:8302271</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bargmeyer S]]
[[Category: Kalenderoglou IE]]
[[Category: Loland CJ]]
[[Category: Nielsen JC]]
[[Category: Pape T]]
[[Category: Salomon K]]
[[Category: Shahsavar A]]