View source for 9esd


==Holo TDO with a bound inhibitor==
<StructureSection load='9esd' size='340' side='right'caption='[[9esd]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9esd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9ESD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9ESD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.103&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5PK:(1~{R})-1-CYCLOHEXYL-2-[(5~{S})-5~{H}-IMIDAZO[1,5-B]ISOINDOL-5-YL]ETHANOL'>5PK</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9esd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9esd OCA], [https://pdbe.org/9esd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9esd RCSB], [https://www.ebi.ac.uk/pdbsum/9esd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9esd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/T23O_DROME T23O_DROME] Catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring (By similarity). Required during larval growth to control the level of potentially harmful free tryptophan in the hemolymph. In the adult the same reaction is the first step in the ommochrome biosynthetic pathway.<ref>PMID:2108317</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Large Structures]]
[[Category: Mac Sweeney A]]
[[Category: Wicki M]]