View source for 9evl


==Crystal Structure of human Collagen Hydroxylysine Galactosyltransferase GLT25D1/COLGALT1: Hg2+ soak for experimental phasing==
<StructureSection load='9evl' size='340' side='right'caption='[[9evl]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9evl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9EVL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9EVL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GDU:GALACTOSE-URIDINE-5-DIPHOSPHATE'>GDU</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9evl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9evl OCA], [https://pdbe.org/9evl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9evl RCSB], [https://www.ebi.ac.uk/pdbsum/9evl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9evl ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/GT251_HUMAN GT251_HUMAN] Familial porencephaly. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/GT251_HUMAN GT251_HUMAN] Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of type I collagen (PubMed:19075007, PubMed:22216269, PubMed:27402836). By acting on collagen glycosylation, facilitates the formation of collagen triple helix (PubMed:27402836). Also involved in the biosynthesis of collagen type IV (PubMed:30412317).<ref>PMID:19075007</ref> <ref>PMID:22216269</ref> <ref>PMID:27402836</ref> <ref>PMID:30412317</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: De Marco M]]
[[Category: Forneris F]]
[[Category: Mattoteia D]]
[[Category: Pinnola A]]
[[Category: Rai SR]]
[[Category: Scietti L]]