View source for 9exn


==The vaccinia minimal RNA polymerase cryo EM structure at 1.9A resolution==
<StructureSection load='9exn' size='340' side='right'caption='[[9exn]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9exn]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9EXN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9EXN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 1.89&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9exn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9exn OCA], [https://pdbe.org/9exn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9exn RCSB], [https://www.ebi.ac.uk/pdbsum/9exn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9exn ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RP147_VACCC RP147_VACCC] Part of the DNA-dependent RNA polymerase which catalyzes the transcription of viral DNA into RNA using the four ribonucleoside triphosphates as substrates. Responsible for the transcription of early, intermediate and late genes. DNA-dependent RNA polymerase associates with the early transcription factor (ETF), itself composed of OPG118 and OPG133, thereby allowing the early genes transcription. Late transcription, and probably also intermediate transcription, require newly synthesized RNA polymerase.[UniProtKB:O57204]
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</StructureSection>
[[Category: Large Structures]]
[[Category: Vaccinia virus]]
[[Category: Fischer U]]
[[Category: Grimm C]]
[[Category: Jungwirth S]]