View source for 9ezc


==Structure of the extracellular subdomain of a homomeric LRRC8C truncation disease mutant==
<StructureSection load='9ezc' size='340' side='right'caption='[[9ezc]], [[Resolution|resolution]] 3.41&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9ezc]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9EZC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9EZC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.41&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ezc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ezc OCA], [https://pdbe.org/9ezc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ezc RCSB], [https://www.ebi.ac.uk/pdbsum/9ezc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ezc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LRC8C_HUMAN LRC8C_HUMAN] Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26824658, PubMed:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24790029, PubMed:26824658, PubMed:28193731). Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress (PubMed:24790029, PubMed:26824658, PubMed:28193731). The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (PubMed:33171122). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658, PubMed:28193731).<ref>PMID:24790029</ref> <ref>PMID:26824658</ref> <ref>PMID:28193731</ref> <ref>PMID:33171122</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Barone A]]
[[Category: Campos-Xavier B]]
[[Category: Dutzler R]]
[[Category: Garavelli L]]
[[Category: Innes MA]]
[[Category: Kellenberger S]]
[[Category: Peng Z]]
[[Category: Peter V]]
[[Category: Quinodoz M]]
[[Category: Rivolta C]]
[[Category: Rutz S]]
[[Category: Superti-Furga A]]
[[Category: Unger S]]