View source for 9ezh


==Structure of single-domain antibody VHH_h4 in complex with human Vsig4==
<StructureSection load='9ezh' size='340' side='right'caption='[[9ezh]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9ezh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Camelidae Camelidae] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9EZH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9EZH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.94&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ezh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ezh OCA], [https://pdbe.org/9ezh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ezh RCSB], [https://www.ebi.ac.uk/pdbsum/9ezh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ezh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VSIG4_HUMAN VSIG4_HUMAN] Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases.<ref>PMID:17016562</ref> <ref>PMID:17051150</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Camelidae]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cianferoni D]]
[[Category: Delgado J]]
[[Category: Dewilde M]]
[[Category: Garcia T]]
[[Category: Maragkou K]]
[[Category: Rousseau F]]
[[Category: Schymkowitz J]]
[[Category: Serrano L]]
[[Category: Vizarraga D]]
[[Category: Zhang Z]]
[[Category: Van der Kant R]]