View source for 9ezj


==Apo human TDO in complex with a bound inhibitor (Cpd-4)==
<StructureSection load='9ezj' size='340' side='right'caption='[[9ezj]], [[Resolution|resolution]] 2.61&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9ezj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9EZJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9EZJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.612&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1H8G:ethyl+(9~{R})-2-methoxy-4-oxidanylidene-9-[[(1~{S})-1-phenylethyl]-[(2-propan-2-ylphenyl)carbamoyl]amino]-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidine-3-carboxylate'>A1H8G</scene>, <scene name='pdbligand=ZIQ:alpha-methyl-L-tryptophan'>ZIQ</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ezj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ezj OCA], [https://pdbe.org/9ezj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ezj RCSB], [https://www.ebi.ac.uk/pdbsum/9ezj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ezj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/T23O_HUMAN T23O_HUMAN] Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin (By similarity).
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mac Sweeney A]]
[[Category: Wicki M]]