View source for 9ezv


==Structure of the single-domain antibody VHH_h2 in complex with human Vsig4==
<StructureSection load='9ezv' size='340' side='right'caption='[[9ezv]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9ezv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9EZV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9EZV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ezv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ezv OCA], [https://pdbe.org/9ezv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ezv RCSB], [https://www.ebi.ac.uk/pdbsum/9ezv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ezv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VSIG4_HUMAN VSIG4_HUMAN] Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases.<ref>PMID:17016562</ref> <ref>PMID:17051150</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Markovic I]]
[[Category: Savvides SN]]