View source for 9fbe


==3-keto-glycoside eliminase/hydratase in komplex with 2-hydroxy-3-keto-glucal==
<StructureSection load='9fbe' size='340' side='right'caption='[[9fbe]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9fbe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacteroides_thetaiotaomicron Bacteroides thetaiotaomicron]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9FBE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9FBE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.93&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1IBU:(2~{R},3~{R})-2-(hydroxymethyl)-3,5-bis(oxidanyl)-2,3-dihydropyran-4-one'>A1IBU</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9fbe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9fbe OCA], [https://pdbe.org/9fbe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9fbe RCSB], [https://www.ebi.ac.uk/pdbsum/9fbe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9fbe ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KDSAH_BACTN KDSAH_BACTN] 3-keto-disaccharide hydrolase that preferentially hydrolyzes 3-keto-trehalose (3-dehydro-alpha,alpha-trehalose) (PubMed:33657378). Important for disaccharide utilization in the human gut (PubMed:33657378). Also shows hydrolysis activity with the glucosinolates glucoraphanin or glucobrassicin, but with much lower efficiency (PubMed:32084341).<ref>PMID:32084341</ref> <ref>PMID:33657378</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bacteroides thetaiotaomicron]]
[[Category: Large Structures]]
[[Category: Kastner K]]
[[Category: Nidetzky B]]
[[Category: Oberdorfer G]]
[[Category: Pfeiffer M]]