View source for 9fnb


==TMEM106B filaments from Biondi bodies (Biondi variant)==
<StructureSection load='9fnb' size='340' side='right'caption='[[9fnb]], [[Resolution|resolution]] 2.64&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9fnb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9FNB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9FNB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.64&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9fnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9fnb OCA], [https://pdbe.org/9fnb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9fnb RCSB], [https://www.ebi.ac.uk/pdbsum/9fnb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9fnb ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Biondi bodies are filamentous amyloid inclusions of unknown composition in ependymal cells of the choroid plexuses, ependymal cells lining cerebral ventricles and ependymal cells of the central canal of the spinal cord. Their formation is age-dependent and they are commonly associated with a variety of neurodegenerative conditions, including Alzheimer's disease and Lewy body disorders. Here, we show that Biondi bodies are strongly immunoreactive with TMEM239, an antibody specific for inclusions of transmembrane protein 106B (TMEM106B). Biondi bodies were labelled by both this antibody and the amyloid dye pFTAA. Many Biondi bodies were also labelled for TMEM106B and the lysosomal markers Hexosaminidase A and Cathepsin D. By transmission immuno-electron microscopy, Biondi bodies of choroid plexuses were decorated by TMEM239 and were associated with structures that resembled residual bodies or secondary lysosomes. By electron cryo-microscopy, TMEM106B filaments from Biondi bodies of choroid plexuses were similar (Biondi variant), but not identical, to the fold I that was previously identified in filaments from brain parenchyma.

TMEM106B amyloid filaments in the Biondi bodies of ependymal cells.,Ghetti B, Schweighauser M, Jacobsen MH, Gray D, Bacioglu M, Murzin AG, Glazier BS, Katsinelos T, Vidal R, Newell KL, Gao S, Garringer HJ, Spillantini MG, Scheres SHW, Goedert M Acta Neuropathol. 2024 Nov 6;148(1):60. doi: 10.1007/s00401-024-02807-w. PMID:39503754<ref>PMID:39503754</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 9fnb" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bacioglu M]]
[[Category: Gao S]]
[[Category: Garringer HJ]]
[[Category: Ghetti B]]
[[Category: Glazier BS]]
[[Category: Goedert M]]
[[Category: Gray D]]
[[Category: Jacobsen MH]]
[[Category: Murzin AG]]
[[Category: Newell KL]]
[[Category: Scheres SHW]]
[[Category: Schweighauser M]]
[[Category: Spillantini MG]]
[[Category: Vidal R]]