View source for 9fot


==Human monocarboxylate transporter 8 bound to Silychristin==
<StructureSection load='9fot' size='340' side='right'caption='[[9fot]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9fot]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Vicugna_pacos Vicugna pacos]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9FOT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9FOT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1IET:(2~{R},3~{R})-2-[(2~{S},3~{R})-3-(hydroxymethyl)-2-(3-methoxy-4-oxidanyl-phenyl)-7-oxidanyl-2,3-dihydro-1-benzofuran-5-yl]-3,5,7-tris(oxidanyl)-2,3-dihydrochromen-4-one'>A1IET</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9fot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9fot OCA], [https://pdbe.org/9fot PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9fot RCSB], [https://www.ebi.ac.uk/pdbsum/9fot PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9fot ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/MOT8_HUMAN MOT8_HUMAN] Allan-Herndon-Dudley syndrome. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/MOT8_HUMAN MOT8_HUMAN] Specific thyroid hormone transmembrane transporter, that mediates both uptake and efflux of thyroid hormones across the cell membrane independently of pH or a Na(+) gradient. Major substrates are the iodothyronines T3 and T4 and to a lesser extent rT3 and 3,3-diiodothyronine (3,3'-T2) (PubMed:16887882, PubMed:18337592, PubMed:20628049, PubMed:23550058, PubMed:26426690, PubMed:27805744, PubMed:31436139). Acts as an important mediator of thyroid hormone transport, especially T3, through the blood-brain barrier (Probable) (PubMed:28526555).<ref>PMID:16887882</ref> <ref>PMID:18337592</ref> <ref>PMID:20628049</ref> <ref>PMID:23550058</ref> <ref>PMID:26426690</ref> <ref>PMID:27805744</ref> <ref>PMID:28526555</ref> <ref>PMID:31436139</ref> <ref>PMID:18636565</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Vicugna pacos]]
[[Category: Coscia F]]
[[Category: Tassinari M]]