View source for 9fp8


==Crystal structure of Anopheles gambiae actin depolymerizing factor==
<StructureSection load='9fp8' size='340' side='right'caption='[[9fp8]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9fp8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9FP8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9FP8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.68&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9fp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9fp8 OCA], [https://pdbe.org/9fp8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9fp8 RCSB], [https://www.ebi.ac.uk/pdbsum/9fp8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9fp8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0NGL9_ANOGA A0NGL9_ANOGA] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Actin is an intrinsically dynamic protein, the function and state of which are modulated by actin-binding proteins. Actin-depolymerizing factors (ADF)/cofilins are ubiquitous actin-binding proteins that accelerate actin turnover. Malaria is an infectious disease caused by parasites of the genus Plasmodium, which belong to the phylum Apicomplexa. The parasites require two hosts to complete their life cycle: the definitive host, or the vector, an Anopheles spp. mosquito, and a vertebrate intermediate host, such as humans. Here, the malaria vector Anopheles gambiae ADF (AgADF) crystal structure is reported. AgADF has a conserved ADF/cofilin fold with six central beta-strands surrounded by five alpha-helices with a long beta-hairpin loop protruding out of the structure. The G- and F-actin-binding sites of AgADF are conserved, and the structure shows features of potential importance for regulation by membrane binding and redox state. AgADF binds monomeric ATP- and ADP-actin with a high affinity, having a nanomolar K(d), and binds effectively also to actin filaments.

Crystal structure of Anopheles gambiae actin depolymerizing factor explains high affinity to monomeric actin.,Lasiwa D, Kursula I FEBS J. 2025 Feb 11. doi: 10.1111/febs.70007. PMID:39932036<ref>PMID:39932036</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 9fp8" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Anopheles gambiae]]
[[Category: Large Structures]]
[[Category: Kursula I]]
[[Category: Lasiwa D]]