View source for 9frp


==Human PARP10 ART domain bound to a phthalazinone-based inhibitor.==
<StructureSection load='9frp' size='340' side='right'caption='[[9frp]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9frp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9FRP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9FRP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1IFB:4-[[4-fluoranyl-3-[[(5~{S})-5-methyl-3-(1,3-thiazol-2-yl)-6,8-dihydro-5~{H}-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]carbonyl]phenyl]methyl]-2~{H}-phthalazin-1-one'>A1IFB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9frp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9frp OCA], [https://pdbe.org/9frp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9frp RCSB], [https://www.ebi.ac.uk/pdbsum/9frp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9frp ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PAR10_HUMAN PAR10_HUMAN] May play a role in cell proliferation. May be required for the maintenance of cell cycle progression.<ref>PMID:15674325</ref> <ref>PMID:16455663</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cohen MS]]
[[Category: Moche M]]
[[Category: Schuler H]]
[[Category: Upadhayaya K]]