View source for 9frr


==Caspase recruitment domain (CARD)==
<StructureSection load='9frr' size='340' side='right'caption='[[9frr]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9frr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lysobacter_enzymogenes Lysobacter enzymogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9FRR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9FRR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9frr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9frr OCA], [https://pdbe.org/9frr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9frr RCSB], [https://www.ebi.ac.uk/pdbsum/9frr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9frr ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PROT2_LYSEN PROT2_LYSEN] Possibly a dedicated protease for substrate gasdermin bGSDM; cleaves the bGSDM precursor, releasing the pore-forming moiety, which integrates into the membrane and triggers cell death. Involved in defense against bacteriophages. When this probable 4 gene operon (bGSDM-FE772_23060-FE772_23065-FE772_23070) is inserted into E.coli it provides nearly 100-fold protection against phages T5 and T6 and about 8-fold against phage T4. The operon without bGSDM no longer protects against phage.<ref>PMID:35025633</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Lysobacter enzymogenes]]
[[Category: Amitai G]]
[[Category: Dym O]]
[[Category: Sorek R]]
[[Category: Wein T]]