View source for 9ftm


==Asgard ESCRT-IIIB membrane-bound protofilament structure==
<StructureSection load='9ftm' size='340' side='right'caption='[[9ftm]], [[Resolution|resolution]] 6.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9ftm]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Candidatus_Heimdallarchaeota_archaeon Candidatus Heimdallarchaeota archaeon]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9FTM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9FTM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ftm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ftm OCA], [https://pdbe.org/9ftm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ftm RCSB], [https://www.ebi.ac.uk/pdbsum/9ftm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ftm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A1Q9PC98_9ARCH A0A1Q9PC98_9ARCH] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
ESCRT-III proteins assemble into composite polymers that undergo stepwise changes in composition and structure to deform membranes across the tree of life. Here, using a phylogenetic analysis, we demonstrate that the two endosomal sorting complex required for transport III (ESCRT-III) proteins present in eukaryote's closest Asgard archaeal relatives are evolutionarily related to the B- and A-type eukaryotic paralogs that initiate and execute membrane remodeling, respectively. We show that Asgard ESCRT-IIIB assembles into parallel arrays on planar membranes to initiate membrane deformation, from where it recruits ESCRT-IIIA to generate composite polymers. Last, we show that Asgard ESCRT-IIIA is able to remodel membranes into tubes as a likely prelude to scission. Together, these data reveal a set of conserved principles governing ESCRT-III-dependent membrane remodeling that first emerged in a two-component ESCRT-III system in archaea.

Asgard archaea reveal the conserved principles of ESCRT-III membrane remodeling.,Souza DP, Espadas J, Chaaban S, Moody ERR, Hatano T, Balasubramanian M, Williams TA, Roux A, Baum B Sci Adv. 2025 Feb 7;11(6):eads5255. doi: 10.1126/sciadv.ads5255. Epub 2025 Feb 7. PMID:39919172<ref>PMID:39919172</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 9ftm" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Candidatus Heimdallarchaeota archaeon]]
[[Category: Large Structures]]
[[Category: Baum B]]
[[Category: Chaaban S]]
[[Category: Souza DP]]