View source for 9fvi


==Crystal structure of 14-3-3 sigma in complex with Tau pS214 peptide and covalent stabilizer JS18==
<StructureSection load='9fvi' size='340' side='right'caption='[[9fvi]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9fvi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9FVI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9FVI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1IF4:1-(3-bromanyl-4-methyl-phenyl)-2-(3-methylphenyl)imidazole'>A1IF4</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9fvi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9fvi OCA], [https://pdbe.org/9fvi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9fvi RCSB], [https://www.ebi.ac.uk/pdbsum/9fvi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9fvi ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity).  p53-regulated inhibitor of G2/M progression.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Brunsveld L]]
[[Category: Ottmann C]]
[[Category: Scheele JJA]]
[[Category: Van den Oetelaar MCM]]