View source for 9fvp


==Crystal structure of 14-3-3 sigma in complex with Tau pS214 peptide and covalent stabilizer JS24==
<StructureSection load='9fvp' size='340' side='right'caption='[[9fvp]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9fvp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9FVP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9FVP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.58&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1IGF:1-(3-bromanyl-4-methyl-phenyl)-2-(4-methylphenyl)imidazole'>A1IGF</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9fvp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9fvp OCA], [https://pdbe.org/9fvp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9fvp RCSB], [https://www.ebi.ac.uk/pdbsum/9fvp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9fvp ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity).  p53-regulated inhibitor of G2/M progression.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Brunsveld L]]
[[Category: Ottmann C]]
[[Category: Scheele JJA]]
[[Category: Van den Oetelaar MCM]]