View source for 9fzq


==Proton conductance by human uncoupling protein 1 is inhibited by both purine and pyrimidine nucleotides==
<StructureSection load='9fzq' size='340' side='right'caption='[[9fzq]], [[Resolution|resolution]] 3.03&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9fzq]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9FZQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9FZQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.03&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=UTP:URIDINE+5-TRIPHOSPHATE'>UTP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9fzq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9fzq OCA], [https://pdbe.org/9fzq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9fzq RCSB], [https://www.ebi.ac.uk/pdbsum/9fzq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9fzq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/UCP1_HUMAN UCP1_HUMAN] Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance (By similarity). Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane (PubMed:24196960, PubMed:28781081). However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria (By similarity).[UniProtKB:P12242]<ref>PMID:24196960</ref> <ref>PMID:28781081</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Lama glama]]
[[Category: Large Structures]]
[[Category: Jones SA]]
[[Category: King MS]]
[[Category: Kunji ERS]]
[[Category: Lacabanne D]]
[[Category: Palmer SM]]
[[Category: Pardon E]]
[[Category: Ruprecht JJ]]
[[Category: Sowton AP]]
[[Category: Steyaert J]]
[[Category: Zogg T]]