View source for 9g4d


==Cryo-EM reconstruction of the full-length H209N mutant E. coli transmembrane formate transporter FocA==
<StructureSection load='9g4d' size='340' side='right'caption='[[9g4d]], [[Resolution|resolution]] 2.97&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9g4d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9G4D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9G4D FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.97&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9g4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9g4d OCA], [https://pdbe.org/9g4d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9g4d RCSB], [https://www.ebi.ac.uk/pdbsum/9g4d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9g4d ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FOCA_ECOLI FOCA_ECOLI] Involved in the bidirectional transport of formate during mixed-acid fermentation (PubMed:23335413, PubMed:24659605, PubMed:30247527, PubMed:33169422, PubMed:35084298, PubMed:35377837, PubMed:35390794, PubMed:8022272). Functions to maintain relatively constant intracellular formate levels during growth, using different mechanisms for efflux and uptake of the anion (PubMed:35377837). Has a strong preference for formate as a substrate in vivo and not other acidic fermentation products (PubMed:23335413).<ref>PMID:23335413</ref> <ref>PMID:24659605</ref> <ref>PMID:30247527</ref> <ref>PMID:33169422</ref> <ref>PMID:35084298</ref> <ref>PMID:35377837</ref> <ref>PMID:35390794</ref> <ref>PMID:8022272</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Hamdi F]]
[[Category: Janson K]]
[[Category: Kastritis PL]]
[[Category: Kyrilis FL]]
[[Category: Tueting C]]